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產品規格
售價
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BN41933R-50ul
50ul
￥1338.00
交叉反應（總）:Human,Mouse,Rat,Dog,Pig,Cow,Horse,;推薦應用:FCM,
BN41933R-100ul
100ul
￥2120.00
交叉反應（總）:Human,Mouse,Rat,Dog,Pig,Cow,Horse,;推薦應用:FCM,
BN41933R-200ul
200ul
￥3140.00
交叉反應（總）:Human,Mouse,Rat,Dog,Pig,Cow,Horse,;推薦應用:FCM,
產品描述
| 英文名稱 | CD109 |
| 中文名稱 | 轉化生長因子β1結合蛋白抗體 |
| 別 名 | p180; 8A3; 150 KDa TGF beta 1 binding protein; 7D1; DKFZp762L1111; E123; Platelet specific Gov antigen; r150; RP11 525G3.1; Activated T cell marker CD109; CD 109 antibody CD109 antigen; CPAMD7; FLJ38569; FLJ41966; Gov system alloantigens on platelets. |
| 研究領域 | 腫瘤 免疫學 細胞表面分子 糖蛋白 淋巴細胞 t-淋巴細胞 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Human, (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, ) |
| 產品應用 | ELISA=1:5000-10000 IHC-F=1:100-500 Flow-Cyt=3ug/test IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 154kDa |
| 細胞定位 | 細胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CD109:901-1000/1445 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產品介紹 | CD109 is a a novel member of the alpha2-macroglobulin (alpha2M)/complement superfamily. It is a glycosylphosphatidylinositol (GPI)-linked cell surface glycoprotein of approximately 170 kd found on endothelial cells, activated platelets and T-cells and on a subset of hematopoietic stem and progenitor cells. Although it has been suggested that T-cell CD109 may play a role in antibody-inducing T-helper function and it is known that platelet CD109 carries the Gov alloantigen system, the role of CD109 in hematopoietic cells remains largely unknown. CD109 has been identified as part of the TGF-beta receptor system in human keratinocytes and upregulation of CD109 expression has been observed in several different types of tumour. Function: Modulates negatively TGFB1 signaling in keratinocytes. Subunit: Heterodimer; disulfide-linked. Interacts with TGFB1 and TGFBR1. Forms a heteromeric complex with TGFBR1, TGFBR2 and TGFBR3 in a ligand-independent manner. Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor. Tissue Specificity: Widely expressed with high level in uterus, aorta, heart, lung, trachea, placenta and in fetal heart, kidney, liver, spleen and lung. Expressed by CD34(+) acute myeloid leukemia cell lines, T-cell lines, activated T-lymphoblasts, endothelial cells and activated platelets. Isoform 5 is expressed in placenta. Isoform 1 is expressed in keratinocytes and placenta. Post-translational modifications: N-glycosylated. 2 forms of 150 (p150) and 120 kDa (p120) exist due to proteolytic degradation from a 180 kDa form. Similarity: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. SWISS: Q6YHK3 Gene ID: 135228 Database links: Entrez Gene: 135228 Human Entrez Gene: 235505 Mouse Omim: 608859 Human SwissProt: Q6YHK3 Human SwissProt: Q8R422 Mouse Unigene: 399891 Human Unigene: 32955 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 姬：8個糖基化位點；2 forms of 150 (p150) and 120 kDa (p120) exist due to proteolytic degradation from a 180 kDa form. |
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