貨號
產品規格
售價
備注
BN40716R-100ul
100ul
￥2120.00
交叉反應（總）:Hu Mo Rat ;推薦應用:IHC-P,
BN40716R-200ul
200ul
￥3140.00
交叉反應（總）:Hu Mo Rat ;推薦應用:IHC-P,
產品描述
| 英文名稱 | Decorin |
| 中文名稱 | 核心蛋白聚糖抗體 |
| 別 名 | Bone proteoglycan II; CSCD; DCN; DCN protein; Dermatan sulphate proteoglycans II; DKFZp686J19238; DSPG 2; DSPG2; PG 40; PG II; PG S2; PG-S2; PG40; PGII; PGS 2; PGS2; Proteoglycan core protein; SLRR1B; Small leucine rich protein 1B; PGS2_HUMAN |
| 研究領域 | 轉錄調節因子 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Mouse, Rat, (predicted: Human, ) |
| 產品應用 | WB=1:500-2000 IHC-P=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 36kDa |
| 細胞定位 | 細胞外基質 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse Decorin:131-230/354 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產品介紹 | Decorin is a member of the small, leucine rich proteoglycan (SLRP) family along with biglycan. Found in the interterritorial region of cartilage, decorin interacts with collagen and other matrix proteins to regulate the cartilaginous matrix. It has been shown to interact with fibronectin, thrombospondin, C1q, epidermal growth factor receptor (EGFR), and TGF beta. It is believed that decorin also plays a role in the cell cycle of chondrocytes. Also known as: Decorin; Bone proteoglycan II; CSCD; DCN; DCN protein; Dermatan sulphate proteoglycans II; DKFZp686J19238; DSPG 2; DSPG2; PG 40; PG II; PG S2; PG40; PGII; PGS 2; PGS2; Proteoglycan core protein; SLRR1B; Small leucine rich protein 1B. Function: May affect the rate of fibrils formation. Subunit: Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT (By similarity). Subcellular Location : Secreted, extracellular space, extracellular matrix. Post-translational modifications: The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin. DISEASE: Defects in DCN are the cause of congenital stromal corneal dystrophy (CSCD) [MIM:610048]. Corneal dystrophies are inherited, bilateral, primary alterations of the cornea that are not associated with prior inflammation or secondary to systemic disease. Most show autosomal dominant inheritance. Similarity: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. Contains 12 LRR (leucine-rich) repeats. SWISS: P28654 Gene ID: 13179 Database links: Entrez Gene: 1634 Human Entrez Gene: 13179 Mouse Omim: 125255 Human SwissProt: P07585 Human SwissProt: P28654 Mouse Unigene: 728830 Human Unigene: 56769 Mouse Unigene: 106103 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 核心蛋白聚糖(decorin)屬高分子蛋白多糖類，為蛋白聚糖(PG)的一種,是轉化生長因子β(TGFβ)的拮抗劑。Decorin在調節細胞粘附、遷移、增殖、膠原纖維形成活性調節及對TGF-β的負反饋調節中起到一定的作用。 |
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